The 2021 Chicago Women's Open was a tennis tournament held in Chicago, Illinois for female professional tennis players, and part of the 2021 WTA Tour.

[1] It was played on outdoor hard courts in the week prior to the 2021 U.S. Open.

This marked the first time since 1997 that a WTA tournament was held in Chicago.

[2] This was Svitolina's sixteenth WTA Tour singles title, and first of the year.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: