The 2021 BGL BNP Paribas Luxembourg Open was a professional women's tennis tournament played on indoor hard courts sponsored by BNP Paribas.

It was the 25th edition of the Luxembourg Open, and part of the WTA 250 tournaments category of the 2021 WTA Tour.

It was held in Kockelscheuer, Luxembourg from 13 to 19 September 2021.

[1] 1 Qualifiers prize money is also the Round of 32 prize money * per team

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry using a protected ranking: