The 2021 Tenerife Ladies Open was a women's tennis tournament played on outdoor hard courts.

[1] It was the first edition of the Tenerife Ladies Open, and part of the WTA 250 series of the 2021 WTA Tour.

It was held at the Abama Tennis Academy in Guía de Isora, Spain, from 18 until 24 October 2021.

[2] This is Li's first career WTA title.

The following players received wildcards into the main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: The following pair received entry using a protected ranking: