It was originally scheduled to start on 23 July 2021 and concluded on 14 May 2022;[1] however, the opening match between VfL Osnabrück and MSV Duisburg had to be postponed after Duisburg was quarantined due to COVID-19 cases, delaying the season start by one day.
[2] From this season onward, the German Football Association will allow clubs to place a sponsor logo on the back of their shirts.
However, KFC Uerdingen could not meet the licensing requirements, sparing Meppen from relegation.
[6] 2 SC Freiburg II moved to the Dreisamstadion after SC Freiburg moved to the Europa-Park Stadion, since their previous home stadium, the Möslestadion, did not meet 3.
[8] 4 SC Verl will play their home matches at the Stadion am Lotter Kreuz since their home stadium, the Sportclub Arena in Verl, did not meet 3.