The 2021 Copa de la Liga Profesional was the second edition of the Copa de la Liga Profesional, an Argentine domestic cup.
Colón won their first top-flight professional title after they defeated Racing 3–0 in the final.
[4] Vélez Sarsfield, top team of the Zone B, were eliminated in the quarter-finals.
[5] The draw for the group stage was held on 3 February 2021, 19:00, at Hilton Hotel in Buenos Aires.
Starting from the quarter-finals, the teams played a single-elimination tournament on a single-leg basis with the following rules:[5][7] Source: AFA