The 2021 Campeonato Ecuatoriano de Fútbol Serie A, known as the LigaPro Betcris 2021 for sponsorship purposes,[1] was the 63rd season of the Serie A, Ecuador's top tier football league, and the third under the management of the Liga Profesional de Fútbol del Ecuador (or LigaPro).
[2] Independiente del Valle were the champions, winning their first league title by defeating Emelec in the finals by a 4–2 aggregate score.
The finals were a double-legged series between the winners of both stages with a penalty shoot-out deciding the champion in case of a tie in points and goals scored.
LDU Portoviejo and El Nacional were relegated after finishing in the bottom two places of the aggregate table of the previous season, being replaced by 2020 Serie B champions 9 de Octubre and runners-up Manta.
By having the greater number of points in the aggregate table, Emelec played the second leg at home.