Barbora Krejčíková defeated Anastasia Pavlyuchenkova in the final, 6–1, 2–6, 6–4 to win the women's singles tennis title at the 2021 French Open.

[2] Krejčíková saved a match point en route to the title, in the semifinals against Maria Sakkari.

Krejčíková and Pavlyuchenkova were the combined lowest-ranked major finalists (numbers 33 and 32, respectively) since the introduction of the computer rankings in 1975 (a feat surpassed just three months later at the US Open).

[a] She was also the first player to win both the singles and doubles titles at the same major since Serena Williams at the 2016 Wimbledon Championships, and the first to do so at the French Open since Mary Pierce in 2000.

[9][10] Sakkari and Tamara Zidanšek became the first Greek woman and Slovenian player to reach the singles quarterfinals and semifinals of a major, respectively.

[11][12][b] Coco Gauff was the youngest player to reach a major quarterfinal since Nicole Vaidišová at the 2006 French Open.