On August 15, 2022, Angel City FC promoted vice president of player development and operations Angela Hucles to general manager, taking on some of the roles previously held by sporting director Eniola Aluko.

There have also been five squad members who have not made a first-team appearance in the campaign: three goalkeepers, Sarah Gorden and MA Vignola, who have long term injuries.

Source: NWSLsoccer.com Angel City FC finished the regular season in eighth place and did not qualify for the NWSL playoffs.

On May 24, 2022, Angel City FC announced a two-year partnership with Liga MX Femenil club Tigres UANL of Monterrey, Mexico.

The agreement included friendlies to be played between the clubs, with the first occurring on August 10, 2022, at the Banc of California Stadium in Los Angeles, and the second in 2023 at Estadio Universitario in Monterrey.