The 2022 Rochester New York FC season was the club's 23rd overall and first in MLS Next Pro.

[2] The club was the only independent team playing in MLS Next Pro, and was one of the two teams from the league to participate in the 2022 U.S. Open Cup, alongside St. Louis City SC 2.

In the final game of the regular season, Rochester New York FC confirmed their qualification for the 2022 MLS Next Pro Playoffs after a 2-2 draw with New York City FC II at home, despite losing in the penalty shootout.

They were knocked out in the Eastern Conference Semifinals by regular season champions Columbus Crew 2.

Source: MLS Next Pro Rochester New York is one of only two MLS Next Pro clubs eligible for the US Open Cup, being an independent team.