The USL League One season started on April 2 and concluded on October 15, 2022.

The Kickers finished the season with 51 total points, five clear of second place, with 14 wins, seven losses, and nine draws.

The Kickers reached the fourth round of the Open Cup, before losing to Major League Soccer expansion side, Charlotte FC.

The Kickers began the 2021 season in April due to the ongoing issues surrounding the COVID-19 pandemic.

Striker Emiliano Terzaghi was the league's top scorer, scoring 18 goals.