Angel City and San Diego, new expansion clubs, competed for the first time in the Challenge Cup.

In the 2021 cup, North Carolina had failed to advance beyond the group stage.

Source: NWSLsoccer.com North Carolina has used a total of 30 players during the 2022 season, and there have been 14 different goal scorers.

There have also been three squad members — forward Valérie Gauvin, who was traded to the Houston Dash on August 23, 2022;[10] midfielder Haleigh Stackpole; and goalkeeper Marisa Bova — who have not made a first-team appearance in the campaign.

Players with name struck through and marked † left the club during the playing season.