[1] Key season-ending injuries to their starters and inconsistencies on both the offensive and defensive sides of the ball ultimately led to a season-ending seven-game losing streak and a third consecutive late-season collapse, as they matched a franchise record of 13 losses in a season that was set in the 2000 and 2018 squads.

The team was also plagued by drama before and during the season, which was seen by some observers as a reason for Arizona's dismal performance in 2022.

[4] This would also signal the end of an era for three-time Defensive Player of the Year winner J.J. Watt, as he officially announced his retirement following an overtime loss to the Tampa Bay Buccaneers.

Following an 11–6 2021 season and a playoff appearance for the first time since 2015, the Arizona Cardinals hoped to become the third consecutive team to win a Super Bowl in their home stadium.

For example, Murray and Kingsbury engaged in a heated sideline argument during a game against the New Orleans Saints.

[7] Murray also criticized Kingsbury’s scheming and said that it was "kinda fucked" following a game against the Los Angeles Chargers.

[8] These incidents and the offseason contract situation caused others, such as former Arizona All-Pro cornerback Patrick Peterson, to question Murray’s character, focus, and work ethic.

[12] Additionally, assistant coach Sean Kugler was fired by the team after he allegedly groped a woman in Mexico City before an international game against the San Francisco 49ers.

[13] The off-field noise and injuries to key players, including Murray, were too much to overcome for Arizona, who cratered to a ghastly 4–13 record.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

Not only did the Cardinals lose to the Eagles at home for the first time since 2001, but they also lost their eighth consecutive game at State Farm Stadium.