[4] Brady's announcement triggered a flurry of free agent signings, re-signings, and restructuring, including Chris Godwin,[5] Leonard Fournette,[6] Shaq Mason,[7] Russell Gage,[7] Carlton Davis,[6] Ryan Jensen,[8] Julio Jones[9] and others.

Tampa Bay visited Dallas on Sunday Night Football, the second year in a row that the Buccaneers faced the Cowboys in primetime in Week 1.

Quarterback Tom Brady, coming off an eventful offseason which saw him retire, unretire, then take an 11-day leave of absence during training camp,[15] started his third season under center for Tampa Bay.

On the first play of the second quarter, Mike Evans broke free on a busted coverage, and was wide open for a 41-yard gain down to the Saints 31.

Mike Edwards picked off Jameis Winston, his third straight interception thrown, and ran it back 68 yards for a touchdown to take control of the game with 4:23 to go.

The Tampa Bay offense was without wide receivers Mike Evans (suspension), Chris Godwin (hamstring), and Julio Jones (knee).

Tampa Bay lined up for a potential game-tying two-conversion attempt, but allowed the play clock to run out, and were flagged for Delay of game.

On the second play from scrimmage, Patrick Mahomes found Travis Kelce for a 16-yard touchdown pass, and built an early lead the Chiefs would never surrender.

With wide receivers Mike Evans, Chris Godwin, and Julio Jones back in the lineup, the Tampa Bay passing offense improved over the previous week.

Tom Brady's pass to Cade Otton appeared to give the Buccaneers a first down, but the ball was spotted short of the line to gain.

Tom Brady's two-point conversion pass to Chris Godwin was knocked down at the goal line, and Tampa Bay fell 20–18 at Pittsburgh.

Tampa Bay lost their third straight game, falling to Baltimore on Thursday Night Football to drop to 3–5 on the season, their worst start since 2018.

In the second quarter, the Ravens failed on a 4th & 2 at the Tampa Bay 9 yard line, then had field goal attempt blocked as time expired.

Tom Brady threw a 1-yard touchdown pass to Cade Otton with 9 seconds left in regulation to lift the Buccaneers over the visiting Rams.

During the game, Brady became the first player in NFL history to eclipse 100,000 passing yards (combined regular season & postseason), and he also achieved his 43rd career fourth quarter comeback, tying the mark set by Peyton Manning.

Tampa Bay defeated the defending Super Bowl champion Rams, snapped a three-game losing streak to Los Angeles, and also avenged a divisional round playoff loss from the previous January.

Brady swiftly moved the Buccaneers down field, including four quick passes to Scotty Miller, and had a 1st & Goal at the Los Angeles 7.

He managed to stay in bounds - forcing Tampa Bay to call their final timeout - but was spotted well short of the line to gain.

It was Tampa Bay's first win in four appearances in the NFL International Series, and the Buccaneers moved back into sole possession of first place in the NFC South.

Jones turned up field and was met at the goal line, but absorbed the hit and managed to skirt inside the pylon for a 31-yard touchdown pass.

Rachaad White broke free for a 29-yard blast, stiff-arming and shoving down defender Quandre Diggs, moving Tampa Bay to the Seattle 43 yard line to start the fourth quarter.

Coming out of the two-minute warning, with the crowd singing "Take Me Home, Country Roads", Rachaad White iced the game with a decisive 18-yard run.

Quarterback Tom Brady threw for 246 yards and two touchdown passes, but the Buccaneers were held scoreless in the fourth quarter, and could not score on two overtime drives.

Brady found Julio Jones for a 26-yard gain down to the Cleveland 48, but since head coach Todd Bowles had chosen not to call a timeout prior to the play, they were left with only 8 seconds on the clock.

Quarterback Tom Brady found rookie running back Rachaad White for a 6-yard touchdown pass with 3 seconds left to lift the Buccaneers over the visiting Saints.

[33] Tampa Bay snapped a four-game home losing streak to rival New Orleans, and swept the season series for the first time since 2007.

After moving downfield with relative ease, a costly holding penalty on Donovan Smith pushed Tampa Bay back into a 2nd & 20 at the New Orleans 45.

With Cincinnati's offense struggling in the first half, Tom Brady threw two touchdown passes in the second quarter (to Russell Gage and Chris Godwin), to make the score 17–0.

In the final minutes of the game, the Buccaneers scored their last touchdown of 2022 via a Tom Brady pass to Cameron Brate, but the outcome was already decided in favor of the Cowboys.

To make matters worse for Tampa Bay amid their season-ending loss, wide receiver Russell Gage was carted off with an injury to his neck and back and was hospitalized.