The 2022 season was the San Francisco 49ers' 73rd in the National Football League (NFL), their 77th overall, and their sixth under the head coach/general manager tandem of Kyle Shanahan and John Lynch.

[4] With a Week 15 win against the Seattle Seahawks, and with the Rams and Cardinals both being mathematically eliminated from playoff contention, they won the NFC West for the first time since 2019 and clinched a playoff berth,[5] also becoming the NFL's first team this season to win their division.

[7] With a 41–23 victory over the Seahawks in the Wild Card round,[8] San Francisco completed a 3–0 sweep of all three games played against Seattle.

The 49ers lost to the Philadelphia Eagles 31–7 in the NFC Championship in which injuries to third-stringer Brock Purdy and fourth-stringer Josh Johnson during the game and first-stringer Trey Lance and second-stringer Jimmy Garoppolo previously in the season made the 49ers unable to stay competitive.

[10] The season was highlighted by the emergence of rookie quarterback Brock Purdy, taken last in the 2022 NFL draft, who started after an injury to Jimmy Garoppolo (who himself replaced the injured Trey Lance) and went 5–0 as the starter to end the regular season before winning his first two playoff games.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Here are the 49ers preseason opponents and schedule.

[72] On May 4, the NFL announced that the 49ers would play the Arizona Cardinals during Week 11 on November 21 at Estadio Azteca in Mexico City, as part of the league's International Series.

The game kicked off at 6:15 p.m. MST/5:15 p.m. PST, and was televised on ESPN, with the Cardinals serving as the home team.