The 2022 season was the New Orleans Saints' 56th in the National Football League (NFL), their 47th playing home games at the Caesars Superdome and their first under head coach Dennis Allen.

Long-time head coach Sean Payton announced his retirement shortly after the Saints 2021 season ended on January 25, 2022.

Prior to his departure, Payton was also the second-longest active tenured head coach in the NFL, only behind Bill Belichick of the New England Patriots.

On May 4, the NFL announced that the Saints played the Minnesota Vikings during Week 4 on October 2 at Tottenham Hotspur Stadium in London, as part of the league's International Series.

The Falcons had the chance to retake the lead in the last second, but Payton Turner blocked their field goal attempt to seal the win and start off the Saints' season at 1–0.

In the fourth quarter, Marshon Lattimore and Mike Evans got into a fight at midfield, resulting in both players being ejected.

This was the first time the Saints had played in the United Kingdom since the 2017 season and their first International Series game as the home team since 2008.

Justin Jefferson put the Vikings back in front five minutes later, only for Greg Joseph to miss the extra point, allowing Wil Lutz to tie the game with a career-long 60-yard field goal.

Joseph put the Vikings back in front again with a 47-yard kick after a long reception by Jefferson with less than 30 seconds to play, only for a Chris Olave catch to put the Saints in range of another game-tying field goal from 61 yards; however, Lutz's kick bounced back off the left upright and the crossbar to give the Vikings a 28–25 win.

After their close loss to the Vikings, the Saints flew back home to the Superdome for their Week 5 matchup against the Seattle Seahawks.

Andy Dalton started his second game at quarterback, but it was utility player Taysom Hill that stole the show in the Superdome that afternoon, who helped guide New Orleans to victory over the fiesty Seahawks 39–32 thanks to a phenomenal 3-touchdown performance from him, the last of which being a 60-yard run that put the Saints ahead for good.

Though the Saints found themselves holding a two-score lead twice during the game, the Bengals pulled out a late fourth quarter comeback victory on a 60-yard touchdown pass from Joe Burrow to Ja'Marr Chase.

Andy Dalton started for the fourth straight game for the Saints on Thursday Night Football against the Cardinals.

The Cardinals would continue their dominance throughout the third quarter, holding the Saints to a field goal while scoring a touchdown of their own to go up 35–17, their largest lead of the night.

In the fourth quarter, despite a late Saints rally in which they outscored Arizona 17–7 to cut the lead to just 8, the Cardinals held on for a thrilling 42–34 victory.

The Saints defense smothered a Raiders offense that had put up a season-high 38 points the previous week, only allowing them to cross midfield once late in the game.

Following their win against the Raiders, the Saints stayed home to face off against the Baltimore Ravens in a Week 9 contest on Monday Night Football.

The Saints would get their first points off the night off a Wil Lutz field goal to cut the deficit to 11 as time expired in the first half.

The Eagles looked like they were making a comeback scoring ten points in the third with the help of their defense, and although they gave up only one touchdown, Minshew threw a pick six to Marshon Lattimore, effectively ending the game.