The 2022 season was the Indianapolis Colts' 70th in the National Football League (NFL), their 39th in Indianapolis, their sixth under the leadership of general manager Chris Ballard and their fifth and final season under head coach Frank Reich.

In the offseason, the Colts acquired former MVP quarterback Matt Ryan in exchange for a third round pick.

This loss, coupled with the Jacksonville Jaguars win over the New York Jets the following Thursday, eliminated the Colts from playoff contention.

Despite the Colts' poor season, one highlight was a week three 20–17 upset win over the eventual Super Bowl champion Kansas City Chiefs.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Colts' preseason opponents and schedule were announced in the spring.

The Colts failed to capitalize on offense, and were shutout for the first time since week 13 of the 2018 season, which was also against the Jaguars.

Neither side scored a touchdown as Russell Wilson and Matt Ryan struggled throughout the game.