The Rams had dealt with notable key injuries to most of their starters including quarterback Matthew Stafford and All-Pros Cooper Kupp and Aaron Donald, all of whom had played prominent roles in the team's Super Bowl run of the previous season.

(There are some teams who did this early in NFL history; for example, the 1921 Chicago Staleys (now Bears) played ten consecutive games in Cubs Park (now Wrigley Field) from October 16 to December 18.

Starting the 2022 campaign at home on Thursday Night Football, the Rams were shut out in the second half as Sean McVay lost a season opener for the first time as head coach.

Rookie cornerback Cobie Durant returned an interception 51 yards late in the second quarter to set up a Rams touchdown and added two tackles including a sack of Falcons quarterback Marcus Mariota.

With a strong defensive performance that kept the Cardinals offense out of the end zone for the entire game, the Rams picked up their first (and ultimately only) NFC West victory of the season.

Rookie cornerback Derion Kendrick and veteran linebacker Bobby Wagner shared the team lead in tackles with nine as they helped to limit the Cardinals to just four field goals by kicker Matt Prater.

The host 49ers racked up seven sacks and dominated the line of scrimmage on both sides of the ball to continue their mastery of the Rams in the regular season with their seventh straight victory.

Meeting Los Angeles for the first time since they lost the 2021 NFC Championship Game, the 49ers gave up an early field goal to Rams kicker Matt Gay but then seized the lead on a 32-yard touchdown run by running back Jeff Wilson and extended their advantage to 14–6 when San Francisco quarterback Jimmy Garoppolo connected with wide receiver Deebo Samuel on a 57-yard catch-and-run late in the second quarter.

Stafford also threw a fourth quarter interception that was returned by San Francisco strong safety Talanoa Hufanga 52 yards for a touchdown and the game's final points.

On the Rams' next possession, Armstrong came up with a second big play, blocking a punt by Riley Dixon and returning it 14 yards down to the L.A. 20 which led to a field goal by Brett Maher and a 9–0 lead.

The Rams answered with a 29-yard field goal by kicker Matt Gay that was set up by a 54-yard deep pass from Stafford to wide receiver Tutu Atwell.

The Rams defense held the visiting Panthers out of the end zone while the offense finally got untracked as Los Angeles evened its record to 3–3 going into the bye week.

Cornerback Jalen Ramsey had three solo tackles including a sack and free safety Nick Scott added an interception to snuff out the Panthers' final offensive drive.

For the Rams, wide receiver Allen Robinson scored on a 5-yard touchdown pass from quarterback Matthew Stafford late in the second quarter and finished with five receptions for 63 yards.

In a rematch of the 2021 NFC Championship Game, the visiting 49ers continued their regular season dominance of the Rams by scoring 21 unanswered points in the second half.

49ers quarterback Jimmy Garoppolo completed 21 of 25 passes for 235 yards and two touchdowns and improved to 8–1 lifetime against the Rams as San Francisco won its eighth straight regular season game over Los Angeles.

With backup quarterback John Wolford starting in place of Matthew Stafford, who was unable to play due to concussion protocols, the Rams' offense continued to struggle as it had all season.

After the Rams' Matt Gay kicked a field goal on their opening drive, the Cardinals scored 17 unanswered points, including two touchdowns inside of the final two minutes of the first half.

A field goal later in the quarter increased Arizona's advantage to 17 points, and the game ended 27–17 after the Rams scored with seven seconds remaining on a TD pass from Wolford to wide receiver Van Jefferson.

Returning to the starting lineup, quarterback Matthew Stafford threw two touchdowns in the first half, but was pulled out of the game midway through the third quarter after taking several hard hits.

With Matthew Stafford sidelined again due to concussion protocols and down their top two receivers, the injury-riddled Rams fell on the road to the AFC-leading Chiefs.

Kansas City drove 90 yards on nine plays midway through the first period to score the game's first points as star quarterback Patrick Mahomes connected with tight end Travis Kelce on a 39-yard touchdown pass.

Free safety Nick Scott killed a Kansas City drive with an interception near the goal line in the fourth quarter, L.A.'s first defensive turnover in five games.

The Rams rallied to take a fourth quarter lead but could not hold on as Geno Smith's 8-yard touchdown pass to DK Metcalf with 36 seconds remaining gave Seattle its first win at Los Angeles since 2017.

Trailing by 13 points with under four minutes remaining, the Rams rallied for an improbable victory and ended their six-game losing streak during a Thursday Night Football game at SoFi Stadium.

Acquired off waivers from Carolina just two days earlier, quarterback Baker Mayfield supplanted starter John Wolford after the first series and led the Rams to a 55-yard field goal by Matt Gay.

The Rams took their first lead of the night, 17–16, with Gay's successful extra point, and a Taylor Rapp interception on the first play after the ensuing kickoff sealed the game.

On defense, Taylor Rapp had his second interception in as many weeks and linebacker Leonard Floyd had two sacks in the game, which dropped the Rams' record to 4–10 while eliminating them from playoff contention.

The Chargers pulled ahead as running back Austin Ekeler ran for touchdowns of 10 and 72 yards in the second quarter to help build a 17–10 halftime lead.

Chargers quarterback Justin Herbert completed 21 of 28 passes for 212 yards and threw two touchdowns in the second half, one to former Rams tight end Gerald Everett in the third quarter.