After a 1–4 start from the team, the Panthers fired head coach Matt Rhule, along with defensive coordinator Phil Snow.

Rhule was replaced with defensive passing game coordinator Steve Wilks, who served as the interim head coach for the remainder of the season.

However, they were eliminated from playoff contention for the fifth straight year when they lost to the Tampa Bay Buccaneers the following week.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

This was head coach Matt Rhule's first return to MetLife Stadium in 10 years, as he had previously served as the Giants' asst.

Things started poorly for the Panthers when, during kick-off, Chuba Hubbard fumbled the ball, and it was recovered by the New York Giants.

In the second quarter, Eddy Piñeiro scores two field goals for the Panthers, tying the game.

The Giants answered back with a Daniel Bellinger touch down, tying the game at 13-13 going into the 4th quarter.

Carolina led by thirteen points at the half after Eddy Piñeiro kicked two field goals in the second quarter.

Early in the fourth, Mark Ingram scores a touchdown for the Saints, giving them their first points of the game.

This was also the last game Christian McCaffrey would play in as a player of the Panthers, as he was traded to the San Francisco 49ers on October 20, 2022.

Chuba Hubbard scored a touchdown in the third, as Ryan Succop made a field goal for the Bucs in the fourth.

In the first half of this blowout, Carolina was scoreless, in part due to poor play from Walker, who posted a 0.0 passer rating, while the Cincinnati Bengals scored 5 touchdowns, four of them from Bengals running back Joe Mixon.

The Panthers went on to score 14 in the fourth, and even though Cincinnati went scoreless, the Bengals kept their comfortable lead and won 42–21.

Carolina sought revenge against Atlanta in this Thursday Night Football game after losing in a heartbreaker 11 days prior.

The Panthers improved to 5–8, and with a Buccaneers loss, also allowed them control of their own destiny, meaning they were guaranteed a spot in the playoffs if they could win out.