[1] The tournament began on 22 June and ended on 13 November, and had 76 teams participating.
[2] Defensor Sporting were the first winners of the competition, defeating La Luz in the final match 1–0.
In the first phase of the national stage, 28 teams from the Primera División Amateur and Segunda División entered the competition, for a total of 48 teams which are divided into 24 ties, with the winners qualifying for the second round.
[1] 32 teams played in the third phase: 12 winners from the previous phase, 16 professional teams from the Primera División, the best relegated team of Primera División the previous season (Progreso), the defending champion of the Primera División Amateur (Miramar Misiones) and the defending champion and runner-up of the Copa Nacional de Clubes (Central and Juventud (Colonia)).
[4] The draw of the competition was held on 14 June 2022, at the Centro Cultural Teatro Español in Durazno.