The 2022 Internazionali di Tennis Città di Vicenza was a professional tennis tournament played on clay courts.

It was the seventh edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Vicenza, Italy between 23 and 29 May 2022.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as special exempts: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: