The season was originally scheduled to start on 21 January 2022, but the date was pushed back due to the detection of several COVID-19 cases in the participating clubs.
The winners of the Apertura and Clausura stages qualified for the playoffs, as long as they ended the season in the top eight of the aggregate table, along with the top two teams on the aggregate table at the end of the season.
The four teams qualified for the playoffs were to play two double-legged semifinals with the winners playing the finals to decide the national champion, unless any of the following conditions is met: The bottom two teams of the aggregate table at the end of the season were relegated, while the 17th placed team of the aggregate table played the Liga 2 runner-up in a double-legged playoff (Revalidación) to remain in Liga 1.
On 20 January 2022 Binacional, who had originally placed 16th in the 2021 Liga 1 aggregate table and were relegated following their defeat to Carlos Stein in the Revalidación, were reinstated in the competition due to a ruling by the Court of Arbitration for Sport which overturned a 3–0 win awarded to Cusco in their Fase 2 match against Cienciano.
[5] On 21 January 2022, the FPF confirmed that they would abide by the CAS ruling and also ruled out a replay of the Revalidación series, this time between Carlos Stein and Universidad San Martín who went up to 16th place in the 2021 Liga 1 aggregate table as an effect of this ruling, with which Universidad San Martín also avoided relegation whilst Carlos Stein's promotion was confirmed, meaning that the league would be contested by 19 teams.