The 2022 Murcia Open was a professional tennis tournament played on clay courts.

It was the 3rd edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Murcia, Spain, between 4 and 10 April 2022.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: