The 2022 Open Castilla y León was a professional tennis tournament played on outdoor hard courts.

It was the 36th edition of the tournament and part of the 2022 ATP Challenger Tour.

It took place in El Espinar, Segovia, Spain, between 25 and 31 July 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: