The 2022 Savannah Challenger was a professional tennis tournament played on clay courts.

It was the twelfth edition of the tournament which was part of the 2022 ATP Challenger Tour.

It took place in Savannah, Georgia, United States between April 25 and May 1, 2022.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: