The 2022 Zagreb Open was a professional tennis tournament played on clay courts.

It was part of the 2022 ATP Challenger Tour.

It took place in Zagreb, Croatia between 9 and 14 May 2022.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following players received entry as lucky losers: