AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney.

Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system.

The AQP1 monomer consists of six transmembrane alpha helices that are connected by five loops (A to E).

The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.