α-Ketoisovaleric acid is an organic compound with the formula (CH3)2CHC(O)CO2H.

With a melting point just above room temperature, it is usually an oil or semi-solid.

It is a metabolite of valine and a precursor to pantothenic acid, a prosthetic group found in several cofactors.

In the biological context, is usually encountered as its conjugate base ketoisovalerate, (CH3)2CHC(O)CO2−.

Like many α-ketoacids, α-ketoisovaleric acid is prone to decarboxylation to give isobutyraldehyde: Genetic engineering has been used to produce the biofuel isobutanol by reduction of isobutyraldehyde obtained from ketoisovalerate.