Botswana competed at the 2022 Commonwealth Games at Birmingham, England from 28 July to 8 August 2022.

Bayapo Ndori and Aratwa Kasemang were the country's flagbearers during the opening ceremony.

[3] The following is the list of number of competitors participating at the Games per sport/discipline.

A squad of seventeen athletes was confirmed as of 1 July 2022.

[2] One weightlifter qualified through his position in the IWF Commonwealth Ranking List (as of 9 March 2022).