Gibraltar competed at the 2022 Commonwealth Games in Birmingham, England between 28 July and 8 August 2022.

Having made its Games debut in 1958, it was Gibraltar's seventeenth appearance to date.

[1] Cyclist Derek Barbara and weightlifter Holly O'Shea were the country's flagbearers during the opening ceremony.

[2] Gibraltar received a quota of 22 open allocation slots from Commonwealth Sport.

[3] One weightlifter qualified through their position in the IWF Commonwealth Ranking List (as of 9 March 2022).