The Isle of Man competed at the 2022 Commonwealth Games in Birmingham, England between 28 July and 8 August 2022.

[1] Cyclist Mark Cavendish and swimmer Laura Kinley were the country's flagbearers during the opening ceremony.

[2] The Games marked the first time since 2002 that the Isle of Man failed to win any medals.

The following is the list of number of competitors participating at the Games per sport/discipline.

Two athletes were selected on 14 September 2021;[3][4] a further two were added on 25 January 2022[5][6] and three more on 5 May 2022.