Papua New Guinea competed at the 2022 Commonwealth Games in Birmingham, England between 28 July and 8 August 2022.

[1] It was the fifteenth time that Papua New Guinea competes at the Games.

Boxer John Ume and Track and field athlete Rellie Kaputin were the country's opening ceremony flagbearers.

[4] Papua New Guinea qualified two players for the table tennis competitions.

[5] Papua New Guinea qualified two weightlifters (one man, one woman) via the IWF Commonwealth Ranking List, which was finalised on 9 March 2022.