Cayman Islands competed at the 2022 Commonwealth Games held in Birmingham, England.

This was Cayman Islands's 12th appearance at the Commonwealth Games.

[1] The Cayman Islands team of 21 athletes competing in six sports was announced on 15 July 2022.

[2] Rasheem Brown and Alison Jackson were the country's flagbearers during the opening ceremony.

[3] The following is the list of number of competitors participating at the Games per sport/discipline.