The municipal address is 14 St. Matthews Road, Toronto, Ontario, at the corner of Broadview Avenue and Gerrard Street.

[3] It became a specialized facility located on the edge of the city to house patients with communicable diseases, such as tuberculosis.

In 1997 as part of Mike Harris' cutbacks the government moved to close the original facility, but a community lobbying effort kept it open, and saved the historic Riverdale Hospital building.

[7] Bridgepoint Active Healthcare and Infrastructure Ontario partnered with Plenary Health to design, build, finance and maintain the new facility for 30 years after completion.

[9][10] The hospital features heavily in the Canadian drama series Orphan Black, where the redeveloped building and the Don Jail serve as the headquarters for the villainous Dyad Group.