3JXT1036912300ENSG00000166862ENSMUSG00000019146Q9Y698O88602NM_006078NM_001379051NM_007583NP_006069NP_001365980NP_031609Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.

It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state.

[5] Stargazin is involved in the transportation of AMPA receptors to the synaptic membrane, and the regulation of their receptor rate constants — via its extracellular domain — once it is there.

As it is highly expressed throughout the cerebral cortex, it is likely to have an important role in learning within these areas, due to the importance of AMPA receptors in LTP.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.