[7] Each is believed to have 12 transmembrane domains and intracellular N and C termini.

Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.

[8] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.

[5] This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub.