The route passes through woodland with some farms and homes prior to coming into the residential and commercial community of Cedarville.

[1][2] At this point, the route turns northeast onto Fairton-Gouldtown Road and heads through wooded areas of homes, crossing a Winchester and Western Railroad line.

Here, the route heads northwest along East Finley Road and passes a mix of farms and homes prior to coming to a junction with CR 611.

After running through a dense area of forest, the route heads into Upper Pittsgrove Township at an intersection with US 40.

The route becomes North Woodbury Road at the latter and widens to four lanes at the point it becomes the border between Pitman to the west and Mantua Township to the east.

Upon crossing the Mantua Creek, the road heads into Deptford Township and passes rural areas of homes.

At the Salina Road intersection, CR 553 becomes the border between Wenonah to the west and Deptford Township to the east running near farmland and wooded residential developments.

The road fully enters Deptford Township again at the Linden Street intersection before crossing into Woodbury Heights.

Upon heading into Woodbury, the route intersects CR 650 at a traffic circle and turns northeast onto Evergreen Avenue.

The road passes a mix of homes and businesses, crossing CR 663 before heading north into residential areas.

After crossing the Woodbury Creek, the route intersects CR 644 in commercial areas and turns north-northeast past more residences.

The highway extends 6.19 miles (9.96 km) from Donald Barger Boulevard (CR 553) in Glassboro to Bridgeton Pike (Route 45) in Mantua Township, passing through Pitman.