Cyclin A2

[6] Cyclin A2 is involved in the G2/M transition but it cannot independently form a maturation promoting factor (MPF).

[10][6] Absence of cyclin A2 before the R point is due to the E2F inhibition by hypophosphorylated retinoblastoma protein (pRb).

[22] Also in mice, cyclin A2 was found to be an RNA binding protein that controls the translation of Mre11 mRNA.

[24] Ccna2 mediated cardiac repair showed both a decrease in fibrosis in the peri-infarct tissue and a greater number of cardiomyocytes at the sites of injection.

[24][25][26] Increased expression of cyclin A2 has been observed in many types of cancer such as breast, cervical, liver, and lung among others.

[6][27][28][29][30] While it is not clear whether increased expression of cyclin A2 is a cause or result of tumorigenesis, it is indicative of prognostic values such as predictions of survival or relapse.