[5] The cyclin B/CDK1 complex also interacts with a variety of other key proteins and pathways which regulate cell growth and progression of mitosis.

The cyclin B/CDK1 complex plays a critical role in the expression of the survival signal survivin.

[6] A decrease in survivin levels and the associated mitotic disarray triggers apoptosis via caspase 3 mediated pathway.

[7] Generally, elevated levels of cyclin B are indicative of more aggressive cancers and a poor prognosis.

Immunohistologically assessed levels of cyclin B could determine if women with stage 1, node negative, hormone receptor positive breast cancer were likely to benefit from adjuvant therapy.

In addition high levels of cyclin B also indicate poor prognosis and lymph node metastasis in gastric cancers.

[12] Therefore, siRNAs for cyclin B may be an effective treatment against cancers where p53 function is inhibited but the gene has not been deleted.