Glacial striations can be found on the rocks of some of the high ridges, but the area was at the margin of the ice sheet, and the impact was much less than in New York just to the north.
The present Susquehanna River established its meandering course during that time, when it was a mature stream on a topography of very low relief.
The Munsee and other native peoples like the Shawnee, Nanticoke, Conoy, and Tutelo were evicted by the terms of the 1768 Treaty of Fort Stanwix, which was between the Iroquois League and the British Crown.
Washington sent Major General John Sullivan on a campaign to destroy the Iroquois threat by a "scorched earth" drive up the Susquehanna and Chemung Rivers into central and western New York.
Quarrying remains an important local industry with the region's high quality blue stone being particularly valuable.