Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels.

[7] Common side effects include liver problems, nausea, joint pain, and a rash.

[12] The adverse effects associated with febuxostat therapy include nausea, diarrhea, arthralgia, headache, increased hepatic serum enzyme levels and rash.

The preliminary results show that overall, febuxostat did not increase the risk of these combined events compared to allopurinol.

[17] Febuxostat is contraindicated with concomitant use of theophylline and chemotherapeutic agents, namely azathioprine and 6-mercaptopurine, because it could increase blood plasma concentrations of these drugs and thereby their toxicity.

[14] It works by non-competitively blocking the molybdenum pterin center, which is the active site of xanthine oxidase.

Febuxostat inhibits both the oxidized and the reduced forms of xanthine oxidase by virtue of its tight binding to the molybdenum pterin site.

[15] After oral intake, at least 84% of the febuxostat dose is absorbed in the gut, and highest blood plasma concentrations are reached after 60 to 90 minutes.

When taken together with a fatty meal, febuxostat reaches lower concentrations in the body; but this is not considered clinically relevant.