Antigua and Barbuda competed at the 2022 Commonwealth Games held in Birmingham, England.

This was Antigua and Barbuda's 11th appearance at the Commonwealth Games.

[1] Antigua and Barbuda's team consisted of 13 athletes (ten men and three women) competing in four sports.

[2] The following is the list of number of competitors participating at the Games per sport/discipline.

Two male road cyclists were selected to the team.