Guyana competed at the 2022 Commonwealth Games at Birmingham, England from 28 July to 8 August 2022.

It was the nineteenth time that Guyana is represented at the Commonwealth Games.

[1] On 5 July 2022, a team of 32 athletes (18 men and 14 women) competing in six sports was announced.

[2] Keevin Allicock and Aliyah Abrams were the country's flagbearers during the opening ceremony.

[2] Guyana qualified men's and women's teams for the table tennis competitions.