[3][4] Hexafluoro-propan-2-ol is a speciality solvent for organic synthesis, particularly for reactions involving oxidations and strong electrophiles.

For example, HFIP enhances the reactivity of hydrogen peroxide as applied to Baeyer-Villiger oxidation of cyclic ketones.

HFIP is inactive, non-genotoxic and once formed, is rapidly conjugated with glucuronic acid and eliminated as a urinary metabolite.

[2] Animal experiments show possible adverse effects on fertility,[10] placing HFIP as a reproductive toxicity category 2 material.

[11] HFIP is a specialty chemical that is produced in small quantities, thus it is not of significant environmental concern.