The first Alice developed rather suddenly on June 24 over the Bay of Campeche, though it may well have formed earlier but went undetected due to limited surface weather observations.

Moving northwestward, Alice strengthened rapidly as it neared the Mexican coastline, becoming a hurricane early the next day.

By midday on June 25, the hurricane reached peak winds of 110 miles per hour (177 km/h) before moving inland well south of the U.S.–Mexico border.

The storm struck an area with few inhabitants and caused relatively minimal impacts from wind near the point of landfall and in southern Texas.

As the river overflowed its banks, floods breached the dikes at Piedras Negras, Coahuila, destroying large sections of the town.

[4][2] Early on that day, a ship calibrated the rapid strengthening of the storm, measuring winds of 85 mph (137 km/h) at 08:17 UTC.

Based on aircraft observations, research suggests that Alice made landfall about 60 mi (97 km) south of Matamoros, Tamaulipas, at 14:00 UTC on June 25.

[3] However, a radiosonde, launched from Brownsville in time for the 12:00 UTC observation, recorded winds of 150 mph (241 km/h) from the southeast at 3,000 feet (914 m) in elevation.

Based on this measurement, which may have represented winds in the eyewall, researchers determined that Hurricane Alice was likely significantly stronger at landfall than previously assessed.

[3] They analyzed Alice as having struck Mexico with winds of 110 mph (177 km/h), while noting the great uncertainty and the possibility that the storm may have even been much stronger than this.

After landing, Hurricane Alice gradually weakened as it approximately followed the Rio Grande, crossing into southern Texas near La Grulla just before 00:00 UTC on June 26.

As it crossed into Texas, Tropical Storm Alice curved more to the north-northwest early on June 26 before assuming a sharp bend back westward later in the day.

[2] The storm degenerated into a tropical depression by 18:00 UTC and dissipated early on June 27 near the Big Bend National Park in Texas.

Weather Bureau posted northwest storm warnings for the Brownsville area, recommending that small boats to stay at harbor.

[13] The destroyed rail lines stranded a Sunset Limited train, which prompted the passengers to evacuate to nearby Langtry.

[12] Heavy rain fell across all of southern Texas and northern Mexico as a result of Alice, causing flash floods in inland areas.

Early on the morning of June 25, a "wall of water" as high as 30 feet (9.2 m) poured out of a dry gully and overwhelmed most of the town.

[7] The Rio Grande rose well above flood level at the cities of Eagle Pass, Texas and Piedras Negras, Coahuila.

[3] Following the devastation left by Alice, members of the U.S. Air Force, Navy, and Army flew 21 helicopters with over 81 tons of relief supplies to the affected people of Mexico and Texas, including food, water, medicine, and clothing.

[17] Leftover waters from the storm led to an increase in mosquitoes in Texas, which prompted a widespread application of larvicide via airplane.