1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9368516410ENSG00000138448ENSMUSG00000027087P06756P43406NM_001144999NM_001145000NM_002210NM_008402NM_001398691NP_001138471NP_001138472NP_002201NP_032428NP_001385620Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins.

In addition to adhesion, many integrins are known to facilitate signal transduction.

[6] In mammals the integrins that include alpha-V are : Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer,[10] and prostate cancer.

[11] The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.