Jefferson is a town in Schoharie County, New York, United States.

The town was first settled around 1793 by New Englanders and was unoccupied by settlers during the American Revolution.

The First Presbyterian Church of Jefferson and Parker 13-Sided Barn are listed on the National Register of Historic Places.

The western town line is the border of Delaware County.

25.0% of all households were made up of individuals, and 9.0% had someone living alone who was 65 years of age or older.