Kanthararom (Thai: กันทรารมย์, pronounced [kān.tʰā.rāː.rōm]) is a district (amphoe) in northeastern Sisaket province, in northeast Thailand.

The district was established in 1897, then named Uthai Si Sa Ket (อุทัยศีร์ษะเกษ).

Neighboring districts are (from the south clockwise): Non Khun, Nam Kliang, Mueang Sisaket, and Yang Chum Noi of Sisaket Province; Khueang Nai, Mueang Ubon Ratchathani, Warin Chamrap, and Samrong.

The district is divided into 16 sub-districts (tambons), which are further subdivided into 169 villages (mubans).

Missing numbers are tambons which now form Nam Kliang District.