Khukhan (Thai: ขุขันธ์, pronounced [kʰùʔ.kʰǎn]) is a district (Amphoe) of Sisaket province, northeastern Thailand.

Neighboring districts are (clockwise, from the north) Prang Ku, Wang Hin, Phrai Bueng, Khun Han, and Phu Sing of Sisaket Province, and Buachet, Sangkha, and Si Narong of Surin Province.

Prior to the re-organization of Thailand for administrative and logistical reasons circa 1945, Khukhan was the provincial capital and is still recognized as the historical center of Sisaket.

The reorganization may have been justified in order to connect all the provincial capitals of the lower northeast by the rail line that runs east-west between Korat and Ubon.

According to local legend, a battle was fought north of the city c. 1400 which prompted the founding of Khukhan by royal decree.