Uthumphon Phisai (Thai: อุทุมพรพิสัย, pronounced [ʔù.tʰūm.pʰɔ̄ːn pʰí.sǎj]) is a district (amphoe) in the western part of Sisaket province, lower northeastern Thailand.

Missing numbers are tambons which now form the districts Mueang Chan and Pho Si Suwan.

Uthumphon Phisai is the home of Prasat Sa Kamphaeng Yai, the biggest Khmer-styled Hindu temple in the province.

Wat Pa Si Mongkhon Rattanaram is a Thai Buddhist temple in Theravāda sect.

Since January 2019 onwards every Friday evening, locals will join to close the road in Kamphaeng to make a cultural pedestrian street named Talat Ban Kao Hao Tamyae.