[9] A mutation in the KCNJ2 gene has also been shown to cause short QT syndrome.

[10] In neurogenetics, Kir2.1 is used in Drosophila research to inhibit neurons, as overexpression of this channel will hyperpolarize cells.

In optogenetics, a trafficking sequence from Kir2.1 has been added to halorhodopsin to improve its membrane localization.

The resulting protein eNpHR3.0 is used in optogenetic research to inhibit neurons with light.

[11] Expression of Kir2.1 gene in human HEK293 cells induce a transient outward current, creating a steady membrane potential close to the reversal potential of potassium.